Pharmaceuticals Intermediates

·       Domperidone & Domperidone Maleate API
a. 1-(3-Chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one
b. 5-Chloro 1,3 dihydro -1- (4-piperidinyl) -2H- benzimidazol – 2 -one
·       Loratadine & Desloratadine API
a. 3(2-(3-Chloro phenyl)ethyl) cyano pyridine
b. 8-Chloro-5,6 dihydro(11H)-benzo[5,6] cyclohepta (1,2b) pyridine -11-one
c. 8 Chloro-11-[(N-methyl)-4-piperidylidene]-6, 11-dihydro-5H-benzo [5,6]cyclohepta (1,2b) Pyridine (Methyl Loratadine)
d. {3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl piperidine-4-yl)

e. N-Methyl-4-chloro piperidine

·       Losartan Potassium API
a. 2-N-Butyl-4-chloro-1-[(2″-H tetrazol-5-yl)(1,1″- Biphenyl)-4yl)Methyl]-1H imidazole-5-methanol(Losartan Base)
·       Olmesartan API
a. 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester)
b. 5-Methoxy – 2-oxo-1,3-dioxol – 4 – yl ) methyl – 4 – (1-hydroxy -1 -methylethyl -2 propyl-1- (2 –(2-triphenylmethyl ) -2H – tetrazole -5 – yl ) biphenyl -4-yl ) methyl ) -1H-imidazole – 5 – carboxylate
c. Ethyl 4 – (1-hydroxy -1 – methylethyl ) -2-propyl-imidazole-5-carboxylate ( OLM 20 )
d. 4-( Cyclomethyl carbonyl ) -5 – methyl – 1,3-dioxol-2-one ( OLM 45 )
·       Telmesartan API
a. [1,1’-Biphenyl]-2-carbonitrile,4’-[(1,4’-dimethyl -2’-propyl [2,6”-bi
b. -1H-benzimidazole ] -1’-yl) methyl ] – (1,1-biphenyl)-2-carbonitrile
·       Loperamide HCl API
a.  4-(4-Chlorophenyl)-4-hydroxy piperidine
b.  N,N-Dimethyl(tera hydro-3,3-diphenyl)-2-furyliden ammonium bromide ( Furanuminium Bromide )
d.  4-Bromo-2-2-diphenylbutyric acid
·       Donepezil API
a. 4-[(5,6-Dimethoxy-1-indanon-2-yl) methyl] piperidine
b.  5,6-dimethoxy-2-(pyridine-4-yl)-methylene-indan-1-one
·       Pantoprazole Sodium API
a.  3,4 Dimethoxy-2-chloromethyl pyridine Hydrochloride
b.  5-(Difluoromethoxy)-2-mercapto-1H- benzimidazole
c. 5-(Difluoromethoxy)-2- {[( 3,4 Dimethoxypyridin – 2- yl) methyl] thio}-1H-benzimidazolee
·       Fexofenadine HCl API
a. Methyl 4-[4-[4-hydroxydiphenylmethyl)-1-piperidinyl]oxobutyl]-2,2-dimethyl benzene acetate
b.  2-(4-(cyclopropanecarbonyl)phenyl)
c.  -2-methylpropanoic acid
·       Cisapride Monohydrate API
a.  Ethyl 4-amino-3-methoxypiperidine-1-carboxylate hydrochloride
b.  4-Amino-5-chloro-2-methoxy-N-(3-methoxy-piperidin-4-yl) benzamide
·       Cyproheptadine HCl API
a. Dibenzosuberenone
b.  N-Methyl-4-chloro piperidine
·       Clopedogrel Bi Sulphate API
a.  s(+) – 2- Chlorophenylglycine methylester tarterate
b.  Toluene-4-sulfonicacid thiophene-2-yl-ethylester
c.  Methyl (2 – Chlorophenyl ){(2-(2-thienyl) ethyl) amino)acetate hydrochloride
·       Nebivolol API
a.  6-Fluoro-3,4-dihydro-2H-chromene – 2-carboxylicacid
b. (6-Fluoro-3,4-dihydro -2H-chromen-2-yl) methanol
c.  (2S)-6-Fluoro-2-[(2S)-oxiran-2-yl)-3,4-dihydro-2H – chromene (Isomer – A )
d.  (2R)-6-Fluoro-2-[(2R)-oxiran-2-yl)-3,4-dihydro-2H – chromene (Isomer – B )
e.  (1S) – 2-(benzyl amino)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol
·       Pimozide API
a.  4-(2-Keto-1-benzimidozolinyl) piperidine
b.  1-Chloro-4,4-di (4-fluorophenyl)butane
a.  4-Chloro-4’-fluoro-butyrophenone (OR)
·       Haloperidol API
a.  4-Chloro-4’-fluoro-butyrophenone (OR)
b.  3-Chloropropyl-4-fluorophenyl ketone
c.  4-(4-Chlorophenyl)-4-hydroxy piperidine
·       Amitriptyline HCl & Nortriptyline HCl API
a. Dibenzosuberone
b. 3-(N,N, Di methyl amino) propylchloride HCl
·       Cyclobenzaprine HCl API
a. Dibenzosuberenone
b. 3-(N,N Di methyl amino) propylchloride HCL
·       Pregabalin API
a. (+)-3-(carbamoy methyl)-5-methyl hexanoic acid
b. (R)-(-)-3-carbamoy methyl)-5-methyl hexanoic acid (OR)
c. (R)-(-)-3-(2-Amino-2-oxo ethyl)-5-methyl hexanoic acid
·       Quetiapine Hemifumarate API
a. 11-Piperazin-1-yldibenzo[b,f][1,4] thiazepine dihydrochloride
b. Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride
·       Fentanyl API
a. 1-(2-phenylethyl) piperidin-4-one
b. N-phenyl-1-(2-phenylethyl) piperidin-4-amine
·       Itopride HCl API
a. 2-[4-(Amino methyl) phenoxy]-N, N-dimethylethanamine
·       Ebastine API
a. 4-(Diphenyl methoxy)-1-piperidine HCl
b. 4-(Diphenyl methoxy)  piperidine
c. 4-Tert butyl-4-chlorobutyrophenone
·       Oxatomide API
a. 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-
b. 1-(Diphenylmethyl) piperazineone
·       Ketorolac tromethamine API
a. Phenyl(1H-pyrrol-2-yl)methanone
b. Triethyl[5-benzyl-1H pyrrol- yl]methane tri carboxylate
c. 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
·       Bepotastine Besilate API
a. α-(-4-Chlorophenyl) pyridine -2-methanol
b. 2-((4-Chlorophenyl) (4-piperdinnyloxy) methyl pyridine
c. 4-Hydroxypiperidine
·       Dolutegravir API
a. (R)-3-Amino-1-Butanol
b. 2,4-Difluorobenzylamine
c. 3-(benzyloxy)-5-bromo-2-methylpuridin-4-ol
·       Linagliptin API
a. (R)-3-(Boc-Amino)Piperidine
b. (R)-3-Piperidinamine dihydrochloride
·       Bicalutamide API
a. 2-2′-[5-(Bromomethyl)benzene-1,3- diyl]bis(2-methylpropanenitrile)
·       Cinnarizine API
a. 1-(Diphenyl methyl) piperazine
·       Dabigatran Etexilate Mesylate API
a. Ethyl – [[3-amino-4-(methylamino) benzoyl]-[pyridin-2-yl-beta-amino] propanoate
b. 2-[(4-cyanophenyl)amino]acetic acid
c. 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester
d. N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester
e. Ethyl 3-(((2-(((4-((((hexyloxy) carbonyl) amino) iminomethyl) phenyl) amino)\methyl)-1-methyl-1H-benzimidazol-5-yl)\carbonyl)(pyridin-2-yl)amino) propanoate
·       Flurbiprofen API
a. Diethyl-2 (3-fluoro-4-nitrophenyl)-2-methylmalonate
b. Diethyl-2-(4-amino-3-fluorophenyl)-2- methylmalonate
c. Diethyl 2-[2-fluro-4-biphenyl-4-yl]-2 methylmalonate
·       Rupatadine Fumarate API
a. 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)-4-piperidinylidene]- 5H-benzo[5,6]cyclohepta[1,2-b]pyridine tri hydrochloride (Rupatadine tri hydrochloride )
·       Dolutegravir Intermediate API
a. 5-Benzyloxy-4-hydroxy-6-hydroxymethyl nicotinic acid
·       Prucalopride API
a. 1-(3-Methoxy propyl) piperidine-4-one
·       Crizotinib API
a. N-Boc-4-hydroxy piperidine
·       Alcaftadine API
a. N-Methyl-4-chloropiperidene
·       Flunarizine Di hydrochloride API
a. 1-[bis(4-fluorophenyl)methyl]piperazine
·       Flusipirilene API
a. 1,1(4-Chlorobutylidene) Bis-(4-fluorobenzene)
·       Rupatadine API
a. 4- Hydroxypiperidine
·       Rifabutin API
a. 1-Isobutyl-4-piperidone
·       Anastrazole API
a. 2-Methyl-oxirane-2-carboxylic acid (4- cyano-3- trifluoromethylphenyl)-amide
·       Eprosartan API
a. 2-Butyl-4-formalimidazole
·       Ketotifene API
a. N-Methyl-4-chloro-piperidine
·       Selexipag API
a. 4-(Isopropylamino)Butanol
b. 5-Chloro-2,3-Diphenylpyrazine
c. 2-Bromo-5,6-Diphenyl Pyrazine
·       Palbociclib API
a. 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
b. 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
·       Prasugrel Hydrochloride API
a. Cyclopropyl 2-fluorobenzyl ketone
b. 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride
·       Febuxostat API
a. Ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
b. Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
c. Ethyl 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
d. Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
·       Aripiprazole API
a. 7-hydroxy-3,4-Dihydro carbostyril
b. 7-(4-Bromobutoxy)-3,4-dihydroquinolin -2-one
c. 1-(2,3- Dichloro phenyl) pipearzine hydrochloride
·       Suvorexant API
a. 2,5-Dichloro-1,3-Benzoxazole
b. N-Benzylglycine Ethyl Ester
·       (S)-+2-amino Butyramide Hydrochloride (SABAM)
·       1-Methylamino-1-Methyl Thio-2-Nitroethane (NMSM)
·       4-Chloro-2-Trifluroacetylanline HCl (E-C HCl)
·       Adenine
·      Asenapine
·      Azilsartan Kamedoximil
·      Bazedoxifene
·      Bazedoxifene Acetate
·       Benzoic Acid, 3-[[(methyl Amino) Thioxomethyl]amino]
·      Benzonatate